口服胶原蛋白减少肌肤皱纹和增加真皮组织的合成(中英)

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摘要:食物营养补充的饮食摄入已被发现有调节肌肤功能的作用,因此它在肌肤衰老的治疗中有着有效作用。然而,支持这些观点的临床性研究数量有限。在此次双盲,安慰剂对照测试中,我们评估了特效生物活性胶原蛋白肽对眼部皱纹形成,I原骨胶原的激活,肌肤中的弹性蛋白和微纤维蛋白生物合成的效用。114名女性,年龄从45到65岁,每57人被安排到其中一个治疗组。她们随意地接受服用2.5克生物活性胶原蛋白肽或安慰剂,每天1次,连续8周。在治疗开始前,治疗4和8周后,以及最后一次服用后的4个星期(4周衰退阶段),每个测试者的皮肤皱纹都有目的性地被测量。我们成立一个副组用于水泡吸收活组织检查来分析被测试者在治疗前和服用8周后肌肤里的I原骨胶原,弹性蛋白和微纤维蛋白。相比使用安慰剂的组别,在这次研究中,摄食特效生物活性胶原蛋白4和8周后,从数据上显示被测试者眼部皱纹明显减少。而且,在口服最后一次生物活性胶原蛋白后的4星期,我们观察到一个正面的,持久的效果。此外,服用8周后,接受生物活性胶原蛋白治疗志愿者的I型原骨胶原和弹性蛋白(18%)含量明显地比起接受安慰剂的病人的高。关于微纤维蛋白,我们确认服用生物活性胶原蛋白肽的人的微纤维蛋白比安慰剂组的高出6%。但这效果未能达到显著地统计水平。总的来说,我们的发现展示出口服特效生物活性胶原蛋白肽减少了皮肤皱纹和对表皮基质合成有着积极作用。

Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis.  AbstractDietary consumption of food supplements has been found to modulate skin functions and can therefore be useful in the treatment of skin aging. However, there is only a limited number of clinical studies supporting these claims. In this double-blind, placebo-controlled study, the effectiveness of the specific bioactive collagen peptide on eye wrinkle formation and stimulation of procollagen I, elastin and fibrillin biosynthesis in the skin was assessed. A hundred and fourteen women aged 45-65 years were randomized to receive 2.5 g of collagen or placebo, once daily for 8 weeks, with 57 subjects being allocated to each treatment group. Skin wrinkles were objectively measured in all subjects, before starting the treatment, after 4 and 8 weeks as well as 4 weeks after the last intake (4-week regression phase). A subgroup was established for suction blister biopsies analyzing procollagen I, elastin and fibrillin at the beginning of the treatment and after 8 weeks of intake. The ingestion of the specific collagen used in this study promoted a statistically significant reduction of eye wrinkle volume (p < 0.05) in comparison to the placebo group after 4 and 8 weeks (20%) of intake. Moreover a positive long-lasting effect was observed 4 weeks after the last collagen administration (p < 0.05). Additionally, after 8 weeks of intake a statistically significantly higher content of procollagen type I (65%) and elastin (18%) in the collagen-treated volunteers compared to the placebo-treated patients was detected. For fibrillin, a 6% increase could be determined after collagen treatment compared to the placebo, but this effect failed to reach the level of statistical significance. In conclusion, our findings demonstrate that the oral intake of specific bioactive collagen peptides reduced skin wrinkles and had positive effects on dermal matrix synthesis.  

来源:www.collagenli.com
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