绝经后骨质疏松症:降钙素和富含胶原蛋白的饮食治疗(中英)

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背景:降钙素对绝经后骨质疏松治疗扮演着重要角色。作者研究了摄取降钙素或富含胶原蛋白的降钙素对骨骼代谢的标识作用。  方法与结果:一组有108个患有绝经后骨质疏松病的病人(骨矿密度少于绝经前期妇女股矿密度的80%)使用100单位CALSYNAR降钙素(罗纳普朗克)治疗,每日服用两次,连续24周。同时期,另外一组49人的妇女口服水解胶原蛋白,每天10克。治疗结束前后,我们对所有病人做了临床和实验室的测试,包括:LS脊柱和右前臂的X光线检查,右前臂的单一光量子测量以及尿排泄物的吡啶诺林,脱氧吡啶诺林和羟脯氨酸的评测。跟基本值对比,治疗后的结果显示骨矿密度仅增加了1.8%,吡啶诺林下降到(62.52%),脱氧吡啶诺林下降到(70.4%)。其数据的区别处于1%的水平。当胶原蛋白被同时摄取时,下降率较显著(分别达到56.22%和56.1%),而接受降钙素治疗组别相对较低(分别下降到67.73%和82.3%),区别率处于明显的5%水平。治疗中断3个月后,吡啶诺林和脱氧吡啶诺林值的下降率保持不变。病人在饮食中服用水解胶原蛋白有效地抑制这些数据上升的发生(分别54.02%和56.66%).  结论:A)连续24周每周口服2次100单位的降钙素导致了骨胶原分解排泄物中的指标数据的下降。B)治疗效用必须由这些指标数据测定。C)口服水解胶原蛋白提高了和延长了降钙素的效用。

Postmenopausal osteoporosis. Treatment with calcitonin and a diet rich in collagen proteins  BACKGROUND:Calcitonin has an important role in the treatment of post-menopausal osteoporosis. The authors investigated the effect of calcitonin administration or calcitonin administration supplement with a diet rich in collagen proteins on markers of bone metabolism.  METHODS AND RESULTS:A group of 108 patients with postmenopausal osteoporosis (BMD lower than 80% of the BMD in premenopausal women) was treated with Calsynar (Rhoune Poulenc-Rorer), 100 u., i.m. twice a week for 24 weeks. Forty-nine of these women took an oral collagen hydrolysate, 10 g per day, for the same period of time. Before and after termination of treatment clinical and laboratory tests were made, X-ray examination of the LS spine and the right forearm, single-photon osteometry of the right forearm and urinary excretion of pyridinoline (UPD), deoxypyridinoline (UDPD) and hydroxyproline (Uhyp) was assessed. As a result of treatment the BMD values increased only insignificantly (by 1.8%) the UPD values declined (to 62.51%) and those of UDPD (to 70.4%), as compared with basal values. The statistical significance is at the 1% level. When collagen proteins were administered concurrently, the decline was more marked (to 56.22% and 56.1% resp.), and as compared with the calcitonin treated group (to 67.73% and 82.30% resp.); the difference is significant at the 5% level. The decline of UPD and UDPD values persisted also three months after discontinued treatment; in patients on the diet with collagen hydrolysate practically no rise of these indicators occurred (54.02% and 56.66% resp.).  CONCLUSIONS:a) administration of 100 u. calcitonin twice a week for 24 weeks led to a decline of excretion indicators of bone collagen breakdown products, b) the effect of treatment must be monitored using these indicators, c) oral administration of collagen proteins enhanced and prolonged the effect of calcitonin.  

来源:www.collagenli.com
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